Memory, Synaptic Translation, and…Prions?
نویسندگان
چکیده
منابع مشابه
Memory, Synaptic Translation, and…Prions?
Two papers from Kausik Si, Eric Kandel, Susan Lindquist, and colleagues set forth a bold new idea for thinking about the mechanisms underlying the generation and maintenance of long-term memories (Si et al., 2003a, 2003b [this issue of Cell]).
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It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA. Therefore, regulation of translation initiation is likely to be intimately involved in modulating ...
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Local protein translation in dendrites could be a means for delivering synaptic proteins to their sites of action, perhaps in a spatially regulated fashion that could contribute to plasticity. To directly test the functional role of dendritic translation of calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) in vivo, we mutated the endogenous gene to disrupt the dendritic localiza...
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all the synapses in the cell? One hypothesis is that syn-aptic plasticity is partially mediated via local production of new proteins only at specific subsets of synapses or individual spines (see Steward and Schuman, 2001, for a review). Ultrastructural studies identified polyribosome complexes and associated membranous cisterns in The Scripps Research Institute dendrites, where they appear to ...
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We describe the use of a translation memory in the context of a reconstruction of a landmark application of machine translation, the Canadian English to French weather report translation system. This system, which has been in operation for more than 20 years, was developed using a classical symbolic approach. We describe our experiment in developing an alternative approach based on the analysis...
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ژورنال
عنوان ژورنال: Cell
سال: 2003
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(03)01022-5